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Pethidine has also been recently reclassified as a Schedule II drug in Canada and was on Oct. 1, 2013, designated as controlled substance 11 under the Canadian Criminal Code . It is restricted in Canada , requiring a prescription for the purchase of pethidine or its derivatives. It is also difficult to obtain in Canada because Health Canada has placed quotas on the drug.
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A similar version of pethidine was synthesized in the 1950s. This precursor was used by chemists in the late 1960s and early 1970s to create a synthetic opioid called pentazocine.[42] In 1982, the FDA approved pentazocine for analgesia, with a recommended dose range of 200 to 1000 mg every four to six hours, and did not approve it for the treatment of cancer pain.[43][44] This approval was based on clinical evidence at that time, and pentazocine is no longer approved by the FDA or any other regulatory body for the treatment of pain.[45] It is used recreationally as a designer drug.[46]
On 26 August 2014, the US Drug Enforcement Administration announced that pethidine would be added to Schedule I of the Controlled Substances Act, and would require an import quota of 1 metric ton per year. The DEA stated that the new scheduling would be effective on 30 September 2014.[47]
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